Anoikis-related genes have been found to play a significant role in the progression of various types of cancer, including ovarian cancer,[8] osteosarcoma,[9] gastric cancer,[10] and breast cancer.[11] One study found that BMP4 promotes resistance to anoikis and chemoresistance in MDA-MB-231 breast cancer cells by upregulating the NOTCH signaling pathway.[12] Additionally, upregulation of the A2 thromboreagin (TP) receptor and the A2 synthetase 1 (TBXAS1) TP receptor has been observed in metastatic breast cancer cells. This evidence concerns the gene TBXAS1 and breast carcinoma.