Activation of the anoikis pathway occurs when cells are detached from the ECM, and anoikis can be avoided when cells are inoculated with anti-integrin antibodies.[17] The mechanism of resistance to anoikis remains elusive; however, some studies have reported that septin is recruited by blebs and interacts with the oncogenic driver NRAS to promote the activation of tumor growth signals. Here, NRAS is linked to neoplasm.