This enhancement can be attributed to the activation and proliferation of T-cells.[25] IKZF3 overexpression can lead to a decrease in PRDM1 expression, which is associated with resistance to anoikis and poorer prognosis in individuals diagnosed with lung cancer.[26] Feng et al developed a prognostic algorithm for breast cancer by utilizing the chromatin regulator-related gene signature and found that IKZF3 had a positive impact on overall survival, which is consistent with the findings of our study.[27]. The gene discussed is IKZF3; the disease is lung carcinoma.