The pathogenesis of the angiomyolipoma is unclear, but in recent years it has been suggested that angiomyolipoma is closely related to tuberous sclerosis.[9]Barnes et al[10] speculated on the pathogenesis of lymphangioleiomyomatosis and angiomyolipoma which the deletion of the tuberous sclerosis 2 gene in neural crest epithelial cells may potentially promote epithelium-to-mesenchymal transition, leading to invasion and migration of mutant cells to distant sites such as the lungs, kidneys, and axial lymphatic vessels and tumorigenesis. The gene discussed is TSC2; the disease is tuberous sclerosis.