Air pollution may cause metabolically associated fatty liver disease (MAFLD), which progresses to liver cirrhosis and HCC.[11–13] Animal studies have suggested that air pollution could trigger oxidative damage and inflammation, which might be involved in the development of chronic liver disease and progression to fibrosis.[14] However, the relationship between air pollution and ALT normalization among CHB patients has not been elucidated. The gene discussed is GPT; the disease is hepatocellular carcinoma.