On the other hand, patients with lower PV-A CO2/CA-V O2 are older and have higher rates of cardiovascular system-related diseases and acute respiratory failure, but patients with higher PV-A CO2/CA-V O2 have higher SOFA, acute physiology score III, and OASIS score indices and are more likely to receive renal replacement therapy and insulin therapy. This evidence concerns the gene INS and respiratory failure.