Pathological results are the gold standard for diagnosis, and the immunohistochemical characteristics of RDD include S100 (+), CD68 (+), and CD1α (−).[9]The imaging features of RDD are hypointensity on T1WI and T2WI and hyperintensity on T1WI with enhancement. The gene discussed is CD68; the disease is sinus histiocytosis with massive lymphadenopathy.