ALB and ischemia: As a result, energy-hungry cells such as neurons become vulnerable, causing irreversible damage, resulting in severe pain and paresthesia.[8] It has been reported that action potentials of motor axons disappear completely at 46 ± 6 min after the onset of ischemia.[9] In addition, the dysfunction of cell membranes due to ischemia causes albumin to enter the interstitium, forming tissue edema due to its hydrophilic nature.