The parallel rising prevalence of obesity and T2D (name "diabesity") present a principal global health challenge with increased risk for overall mortality [3]. In patients with T2D, Glucagon-like peptide-1 receptor agonists (GLP-1Ras) improve the regulation of glucose homeostasis, weight-losing, and long-term benefit cardiovascular outcomes, which have been demonstrated to be accompanied by improved micro- and macrovascular risk factors [4, 5]. This evidence concerns the gene GLP1R and obesity due to melanocortin 4 receptor deficiency.