This chromosome loop was further confirmed via the chromosome conformation capture (3C) assays on A375, SK-MEL-28 (another BRAFV600E melanoma cell line), and SK-MEL-2 (no BRAF mutation melanoma cell line) cells at different conditions (Fig. 5c and Additional file 1: Fig. S5a-f). The gene discussed is BRAF; the disease is melanoma.