CTCF and melanoma: Furthermore, several chromatin remodelers (e.g., SMARCA4, H2AZ, PRMT1, RCOR1) and architecture proteins (e.g., CTCF, MAX) displayed high enrichment scores at these enhancers (Fig. 3d), suggesting that disruption of epigenomic regulation on non-coding regulatory elements may be essential in melanoma tumorigenesis.