Also, contrast with stage 1 and stage 2 neuroblastoma, ZNF436 was down-regulated in stage 4 neuroblastoma patients in E-MTAB-1781, GSE13136, GSE73517, TARGET, GSE16476, GSE62564 and GSE85047 datasets (Fig. 4c). This evidence concerns the gene ZNF436 and neuroblastoma.