Recently, a study found that the S. japonicum egg-derived protein SjE16.7 may induce the progression of CRC,it binds to the receptor for advanced glycation end products (RAGE) and activates the NF-κB signaling pathway, leading to an increase in reactive oxygen species, as well as pro-inflammatory cytokines IL-6 and TNF-α. Here, TNF is linked to colorectal carcinoma.