The positive relationship between Hs-cTnI concentration and all-cause mortality was observed solely in the prediabetes subgroup [HR (95% CI), 2.27 (1.44, 3.58) for Hs-cTnI concentration ≥ 99th URL, compared to Hs-cTnI concentration < LOD]. The gene discussed is TNNI3; the disease is prediabetes syndrome.