MAPT and early-onset autosomal dominant Alzheimer disease: We examined tau PTMs in the sarkosyl-insoluble fractions extracted from five to six cases each of Alzheimer’s disease, PiD, PSP and CBD brains in the same way as described for those from SH-SY5Y cells (Fig. 3A, Table 1, Supplementary Fig. 1 and Supplementary Tables 10–13).