MAPT and Alzheimer disease: Immunoblot analysis with tau 360–380 antibody recognizing the filament core region revealed various sizes of trypsin-resistant tau, 16, 15, 13 and 12 kDa in seeded AD-tau, 13 kDa in seeded PiD-tau, 14, 13.5, 13, and 12.5 kDa in seeded PSP-tau and 16, 13.5, 13 and 12.5 kDa in seeded CBD-tau (Fig. 1B and Supplementary Fig. 2).