For example, a study by Yang et al. [40] found that EEVs loaded with circular RNA SCMH1 (circSCMH1) were able to reduce the inhibition of methylCpG-binding protein 2 (MeCP2) target gene transcription, leading to enhanced neuronal plasticity, inhibition of glial cell activation, and improved functional recovery in rats and monkeys after stroke. Here, MECP2 is linked to stroke disorder.