For example, a study by Yang et al. [40] found that EEVs loaded with circular RNA SCMH1 (circSCMH1) were able to reduce the inhibition of methylCpG-binding protein 2 (MeCP2) target gene transcription, leading to enhanced neuronal plasticity, inhibition of glial cell activation, and improved functional recovery in rats and monkeys after stroke. This evidence concerns the gene SCMH1 and stroke disorder.