RECK and gastric cancer: According to the univariate and multivariate Cox regression analyses of this study, age (HR = 1.032, 95% CI 1.006–1.042, p = 0.00077), stage (HR = 1.556, 95% CI 1.098–2.203, p = 0.013) and RECK expression (HR = 0.644, 95% CI 0.452–0.919, p = 0.015) were identified as independent prognostic factors for overall survival in gastric cancer patients (Fig. 2D).