5-hydroxytryptamine 2C receptor (HTR2C) and SAM and SH3 domaincontaining protein 1 (SASH1) were the genes targeted by tRF-Ser-GCT-113, which were associated with stress sensitivity and clinical mood disorders [118], suggesting that tRF-Ser-GCT-113 may trigger patients to develop abdominal discomfort, bloating, and other symptoms by acting on HTR2C and SASH1. While length of tRF-Gln-TTG-035 is 14 nt, low expressed in intestinal mucosa of IBS patients. Here, HTR2C is linked to irritable bowel syndrome.