PCSK9 and coronary artery disorder: HMGCR and PCSK9 GRS explained 0.54% and 0.27% of LDL-C, and thus, our study was adequately powered to detect an odds ratio of 0.77 and 0.67 per SD reduction in LDL-C for CAD and a beta coefficient of ± 0.46 and ± 0.60 per SD reduction in LDL-C for the continuous outcomes.