In DCM, genetic variants have been most commonly identified in TTN (15–25%) [28, 29] and LMNA (5–10%), followed by sarcomere-related genes (such as MYH6, MYH7, MYBPC3, TNNT2, TNNI3, TNNC1, TPM1, and ACTC1) (10%) [30] and desmosome-related genes (DSP and PKP2) (5%) [31]. The gene discussed is TPM1; the disease is familial dilated cardiomyopathy.