Among 19 patients with DCM exhibiting positive results, TTN variants (5/19 pts, 26.3%) were most frequently detected, followed by LMNA (4/19 patients; 21.1%), MYH7 (4/19 patients; 21.1%) variants and TNNT2 (1/19 patients; 5.3%), DSP (1/19 patients; 5.3%), PRNP (1/19 patients; 5.3%), PLN (1/19 patients; 5.3%), VHL (1/19 patients; 5.3%)and MYLK2 (1/19 patients; 5.3%) variants (Fig. 2). The gene discussed is PRNP; the disease is familial dilated cardiomyopathy.