Using as an example the MCI model 3, a female MCI patient with no history of depression, with a MMSE score of 28, an ADAS score of 13, a RAVLT score of 35, a LM-DR score of 5, a FAQ score of 2, hippocamppal volume of 8.6 cm3, whole brain volume of 1061.8 cm3, a CSF Aβ level of 255 pg/ml, a CSF p-tau level of 20.4 pg/ml, and a PHS score of 0.05 had a predicted risk of AD dementia of 1.8% at the first year and 12.3% at the fifth year after initial evaluation. The gene discussed is MAPT; the disease is major depressive disorder.