MAPT and depressive symptom measurement: ADAS11, MMSE, RAVLT, LM-DR, FAQ, history of depression, hippocampus volume, whole brain volume, CSF Aβ, CSF p-tau and polygenic hazard score were selected as final variables in MCI Model 3 (APOE ε4 was not included as candidate variables in MCI Model 3 because it was included in PHS).