TGFB1 and neoplasm: These pathological cells exert an immunosuppressive effect due to the overproduction of interleukin-10 (IL-10), transforming growth factor-β (TGFβ), arginase and nitric oxide (iNOS) in the tumor microenvironment, and also promote tumor growth by expressing T cell-inhibiting cell surface receptors [4, 7, 8].