TP53 and Familial prostate cancer: GAD1 was significantly involved in the gene pathway ensemble related to the following in prostate cancer: tumor inflammation (p = 3.88e−05), EMT marker (p = 1.64e−11), ECM-related gene (p = 2.92e−09), anglogenesis (p = 1.05e−08), apoptosis (p = 2.17e−08), inflammatory response (p = 1.79e−07), p53 pathway (p = 1.43e−10), TGFβ (p = 2.11E−07), IL10 anti-inflammatory signaling pathway (p = 0.001), genes up-regulated by reactive oxigen species (p = 0.001), collagen formation (p = 1.86e−16) and degradation of ECM (p = 1.14e−12) (Additional file 4: Fig. S4).