Furthermore, after L. casei & L. reuteri or TAK-242 treatment, the expressions of CD86 (Fig. 3F) and iNOS (Fig. 3G) were increased in tumor tissues, whereas the expressions of CD206 (Fig. 3F) and Arg-1 (Fig. 3G) were decreased at the same time. The gene discussed is ARG1; the disease is neoplasm.