The inhibitory potential of UNBS1450 on protein synthesis took place in both sensitive and resistant AML cell models (e.g., M5 THP-1 and M6 Hel) as well as in non-cancer cell models, as the quiescent peripheral blood mononuclear cells (PBMCs), the proliferating cord blood-derived (CB) CD34+ myeloid cells, and phytohemagglutinin (PHA)/interleukin (IL)-2-stimulated PBMCs (Fig. 5D and Supplementary Fig. S12B, C). This evidence concerns the gene CD34 and acute myeloid leukemia.