PKN3 and colorectal cancer: In search for such candidates, we compared the phosphoproteomes of RKO cells (human colorectal cancer cells expressing high PKN3 levels according to ProteomicsDB53) in response to the same three compounds (that only share PKN3 as a target), as well as THZ1 (a covalent inhibitor for which PKN3 is a reported off-target51) and in response to siRNA-mediated knockdown of PKN3 (Extended Data Fig. 9a,b).