CD33 and neoplasm: We further analyzed bulk RNA-sequencing (RNA-seq) data across three AML tumor datasets (The Cancer Genome Atlas (TCGA) and BEAT AML datasets (adult) and the TARGET dataset (pediatric))36–38 and found high blast expression of ITGB2 transcript across AML genotypes as well as potential complementarity with CD33 and IL3RA (CD123) (Fig. 2e and Extended Data Fig. 4a).