Both lipid peroxidation and lipid ROS production were significantly diminished in ACSL4 or FADS2 loss-of function edited AML cell lines, demonstrating that imetelstat-induced lipid peroxidation and lipid ROS production are dependent on functional FADS2 and ACSL4 in vitro (Fig. 4b,c). The gene discussed is FADS2; the disease is acute myeloid leukemia.