Both lipid peroxidation and lipid ROS production were significantly diminished in ACSL4 or FADS2 loss-of function edited AML cell lines, demonstrating that imetelstat-induced lipid peroxidation and lipid ROS production are dependent on functional FADS2 and ACSL4 in vitro (Fig. 4b,c). This evidence concerns the gene ACSL4 and acute myeloid leukemia.