We found that WNT35, MAPK, MTOR, and NOTCH signaling pathway36, which are all related to poor prognosis of liver cancer, were activated by NR6A1, OSBP2 and UNC119B. Selvaggi et al. assumed that targeting the WNT/β-catenin pathway was important to identify therapeutic agents for HCC37. The gene discussed is MTOR; the disease is liver cancer.