TGS1 and cancer: One such process, 5’ capping of telomerase RNAs by Tgs1 in Cajal bodies (Verheggen et al. 2002) has been identified as a potential therapeutic target, where alleviating Tgs1 capping of telomerase RNAs and inhibiting telomerase action could treat cancers, or increasing Tgs1-telomerase RNA functionality could be used for treating premature ageing disorders (Buemi et al. 2022).