Finally, to determine if the limited role of amphiregulin during NOD spontaneous diabetes development was organ specific, and if amphiregulin could have a functional role in other types of autoimmunity, we induced experimental autoimmune encephalomyelitis (EAE), a well-established model of multiple sclerosis, in 7-week-old female C57BL/6.Areg−/− and littermate wild-type control mice. This evidence concerns the gene AREG and multiple sclerosis.