Additionally, the increased release of vascular endothelial growth factor (VEGF) from natural killer (NK) cells co-incubated with DHEAS was found in patients with vascular dementia (VAD) and AD, while NK cells co-incubated with Aβ1-42 entirely inhibited the VEGF release in patients with VAD and AD163. This evidence concerns the gene VEGFA and Alzheimer disease.