Three regulons (gene networks regulated by AE binding protein 1 (AEBP1), thyroid hormone receptor beta (THRB) and zinc finger protein basonuclin zinc finger protein 2 (BNC2)) contained substantially greater numbers of the TRS genes than expected by chance, indicating that these three networks may be critical to MASLD disease progression leading to decompensation events. The gene discussed is BNC2; the disease is metabolic dysfunction-associated steatotic liver disease.