HAS2 and neoplasm: We also observed similar trends of mRNA expression levels in lungs of tumor-bearing mice (Supplementary Figures 3-4) in the same genes that exhibited significant, or close to significant, upregulation in MDA-MB-231 conditioned fibroblasts in our cell culture studies, namely Col14A1, GPC1, GPC3, HAS2, MMP1, MMP2, MMP10 and MMP14.