Previous studies have shown that LOX increased in premetastatic sites in the lungs through increased expression and secretion from breast cancer cells in the primary tumor, which was induced by hypoxia-inducible factor 1 alpha (HIF1-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α) under hypoxic conditions16. This evidence concerns the gene HIF1A and neoplasm.