In the AKI group, urinary levels of [TIMP-2] × [IGFBP7] significantly increased post-operation (P < 0.05), 4-h post-operation (P < 0.05) and on PODs 2 (P < 0.05) and 3 (P < 0.01) compared with those pre-operation (Fig. 1). This evidence concerns the gene TIMP2 and acute kidney injury.