Somatic mutations in RUNX1 are associated with the progression of chronic myelogenous leukemia (CML) to blast crisis [2], and chromosomal translocations resulting in the generation of fusion genes such as RUNX1-ETO, RUNX1-EVII, etc., are frequently reported in leukemia [3]. The gene discussed is RUNX1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.