APOE and atherosclerosis: Given the role of EndMT in atherosclerosis and the protective effect of adropin on endothelial cells, we attempted to determine the role of EndMT in adropin-induced anti-atherosclerosis using the HFD-fed ApoE-/- and ApoE-/-/Enho-/- double-gene-knockout (DKO) mouse models and the in vitro hydrogen peroxide (H2O2)-induced EndMT model.