MEG3 and type 1 diabetes mellitus: Colocalization with the MEG3 eASQTL identified rs56994090 (chr14:101306447:T > C, PP = 100%) as the most likely candidate causal variant, which is concordant with the findings of a previous GWAS study84 (Supplementary Data 14). Of note, rs56994090 is in strong LD with an indel (rs34552516), which was previously identified as a candidate causal variant.85 Given that rs56994090 is located in the novel intron enhancer of MEG381, we hypothesize that alternative splicing of MEG3 may alter the enhancer’s regulatory function, as previously observed in other lncRNAs86, and thereby, affect T1D-risk.