Furthermore, we for the first time demonstrate from in vivo that Talin-1 and Stat3 functions in the same genetic pathway in β-cells to regulate glucose homeostasis in mice, and mice of double heterozygous for Talin-1 and Stat3 in islet β-cells display severe glucose intolerance, impaired GSIS and reduced β-cell mass compared to either singly heterozygous or control mice. Here, TLN1 is linked to Glucose intolerance.