TLN1 and type 1 diabetes mellitus: Besides, similar to changes of Talin-1 expression (Fig. 1), single cell analysis revelaed that genes involved in the progression from G1 to S phase were generally up-regulated in T1D and T2D, and b-cells showed significant higher level of S scores in diabetic diseases, which may be a compensatory mechanism of the body (Supplementary Fig. 2A, B).