We further investigated the role of Stat3 in mediating the effect of Talin-1 defficiency on glucose intolerance by deleting one allele of Talin-1 and/or Stat3 genes specifically in β-cells with the same Ins2-Cre mice, and we obtained Talin-1 or Stat3 singly heterozygous mice (i.e., Talin-1fl/+; Ins2-Cre or Stat3fl/+; Ins2-Cre) and double heterozygous mice (i.e., Talin-1fl/+; Stat3fl/+; Ins2-Cre). This evidence concerns the gene STAT3 and Glucose intolerance.