Our study results on the dryness of KCNQ4, TMB and MSI emphasize the strong correlation between the expression of KCNQ4 and the dryness and heterogeneity of tumor genomes, especially in BRCA, CESC, LIHC, BLCA, which may play a role in improving the status quo of clinical treatment of cancer. Here, KCNQ4 is linked to cancer.