Eosinophils are thought to amplify the Th1 immune response indirectly by promoting macrophage M1 skewing via IFN-γ and TNF-α production as well as contribute to the normalization of tumor vasculature resulting in tumor rejection (Biswas & Mantovani, 2010; Varricchi et al., 2017). The gene discussed is IFNG; the disease is neoplasm.