SLC7A10 and Global developmental delay: During childhood at the age of two years, the motor phenotype was paralleled by a developmental delay suggesting that both inhibitory and excitatory pathways were affected at the molecular level in line with the dual role of Asc-1 in excitatory and inhibitory processes (Helboe et al., 2003; Rosenberg et al., 2013; Safory et al., 2015; Ehmsen et al., 2016; Sason et al., 2017).