To investigate whether LXY18 displayed a similar pattern in these cells or harbors distinct, unknown limitations, we examined the cytotoxicity of LXY18 in a panel of 18 human cancer cell lines, including some cell lines poorly responsive to AURKB inhibitors, which we uncovered using the cancer cell line Dependency Map Portal (DepMap; https://depmap.org/portal/) (S1 Table). The gene discussed is AURKB; the disease is cancer.