Although we have not detected differences in mRNA expression of the 12-S-HETE biosynthetic proteins, or the 12-S-HETE receptor (GPR31) between winner and loser GSCs, in human prostate cancer expression levels of GPR31 and 12-S-HETE both positively correlate with metastasis [48, 49]. Here, GPR31 is linked to Familial prostate cancer.