IGF2 mRNA was over-expressed in both HCC-like and HB-like components, however, 11p15 cn-LOH was only detected in the HCC-like component, suggesting that perhaps other mechanisms, such as recently reported epigenetic abnormalities in the HB component, may account for IGF2 over-expression in the HB component. Here, IGF2 is linked to hepatocellular carcinoma.