AKT1 and cancer: From the earliest observations of Akt and mTORC1 in nuclear fractions of cell lysates, multiple groups have been attracted to the potential of Akt/mTORC1-mediated transcriptional regulation controlling survival, protein synthesis, and the metabolic capacities of the cell, especially considering the hyperactivation of Akt and mTORC1 in some cancers [54–57].