MRC1 and age-related macular degeneration: Immunohistochemistry for VEGF and CD206 (mannose), both accepted as M2a markers (Kadomoto et al., 2021; Brüne et al., 2015), demonstrated that monocytes from AMD patients polarized into M2a phenotypes following delivery to the mice eye in the photic retina injury model (Figure 1—figure supplement 1K–S).