Increased levels of C-reactive protein and complement activation have also been measured in the plasma of patients with AMD (Seddon et al., 2004), and histological analyses of AMD eyes revealed the presence of macrophages in the vicinity of the atrophic lesion (Cao et al., 2011; Lad et al., 2015; Buschini et al., 2011), as well as in drusen (Penfold et al., 2001) and the subretinal space (Sennlaub et al., 2013). This evidence concerns the gene CRP and age-related macular degeneration.