Results of our in vivo study consistent with previous reports (Ullah et al. 2022; Feng et al. 2012; Itani et al. 2016; Zherebiatiev and Kamyshnyi 2016) and our bioinformatics analysis demonstrated a marked up-regulation of the inflammatory status with increased expression of NF-κB, NLRP3, cleaved caspase-1 and significant elevation of colonic IL-1β in mice subjected to oxazolone-induced colitis. This evidence concerns the gene NFKB1 and colitis.