CA12 and cancer: The CA II plays a relevant physiologicalrole and is found highly expressed not only in red blood cells, thegastrointestinal tract, the lungs, and the kidneys7 but also in some types of cancer, such as urothelial carcinoma.8 Both isoforms are involved in glaucoma,9 epilepsy,10 and Parkinson’sdisease.11 The human-membrane-associatedCA IX and CA XII enzymes catalyze the hydration of carbon dioxidein the extracellular space.