The detection results of NAFLD mice revealed a decrease in MMP (P < 0.05, Figure 2A), an increase in the expression levels of mitochondrial fission proteins, namely, mitochondrial fission 1 protein (Fis1) and Drp1, and a decrease in the fusion protein Mfn2 expression (P < 0.05, Figure 2B). Here, FIS1 is linked to metabolic dysfunction-associated steatotic liver disease.