During AD, basophils stimulated by allergens contribute to the exacerbation of AD pruritus through the release of leukotriene C4 that binds to the cysteinyl LT receptor 2 on itch‐associated nonpeptidergic neurons and mediates itch via TPPA1 and TRPV1.15 The gene discussed is TRPV1; the disease is Alzheimer disease.