The main research themes during the last decade have surrounded the neural and itch‐specific molecules or pathways related to immunity, including “GRP,” “interleukin‐31 receptor,” and “substance p.” The exploration of the mechanisms of itch production in “AD,” a pruritic disease closely related to neuroimmunity, has been of great research interest in recent years. The gene discussed is TAC1; the disease is Alzheimer disease.