Accordingly, our results demonstrated that several genes involved in the inflammatory response, including well‐known proinflammatory genes Il1a, IL23, Cxcl6, Cxcl1, and genes specially expressed in immune cells such as Tnrsf9 and Tnrsf11b were higher in CVT, which will provide potential diagnosis and treatment targets for CVT. Here, CXCL6 is linked to congenital vertical talus.