For instance, in GBM stem‐like cells (GSCs) with methylated O6‐methylguanine‐DNA methyltransferase promoter (MGMT‐m), CHI3L1 functioned as a tumour suppressor gene, sensitizing GSCs' response to temozolomide (TMZ) by activating DNA damage responses (DDRs). Here, CHI3L1 is linked to neoplasm.